Abstract
Preclinical studies often overlook lung mucus barriers, crucial for drug permeation. This research uses a patient-derived 3D cell culture model to examine lanthanide-doped upconverting nanoparticles (UCNPs) with different surface coatings. Tracking UCNPs via upconverting emissions reveals significant differences in mucus residence time and mucociliary clearance. Positively charged,...
The climate is a nonlinear dynamical system driven by the inhomogeneous energy received from the Sun. The redistribution of energy involves a multitude of processes acting at various spatial and temporal scales. These processes are interconnected, leading to the existence of a multitude of feedback loops that can amplify or compensate each other.
A steady state is reached when a balance...
(Poster) Cosmological observations are well described by the LCDM model, a universe with a cold dark matter component and a cosmological constant acting as dark energy. However, more and more cosmological tensions have emerged in the past decades, putting this simple model into question. A large amount of research has focused on the quest for an alternative model of modified gravity and dark...
The T2K[1] collaboration is upgrading the near detector (ND280) with four additional subdetectors: a time of flight detector (TOF), two high-angle TPCs (HATPC), and the super fine grained detector (Super-FGD).
The Super-FGD consists of 2 million scintillator cubes read by optic fibers along three directions, allowing three-dimensional track reconstruction in a 2-tons fiducial mass...
The highly energetic nature of gamma rays renders their terrestrial observation impossible, as they interact with the atmosphere, producing particle showers. These particles then become a source of Cherenkov radiation, subsequently detected by an array of ground-based telescopes. Their cameras record images which are then parametrized. The parameters are fed to random forests to reconstruct...
Proton beam therapy can potentially offer improved treatment for cancers of the head and neck and in paediatric patients. Proton therapy is a promising new type of cancer treatment, can be targeted more directly at the tumor and does less damage to other tissue. Treatments are currently planned using conventional X-ray CT images. It is happening due to the absence of devises able to perform...
